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When given baclofen, both groups of rats showed a decrease in the number of times heroin was self-administered.

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In severe cases, bolus administration via lumbar puncture may be needed until catheter reinsertion is attempted.

Give special attention to patients at apparent risk (eg, spinal cord injuries at T-6 or above, communication difficulties, history of withdrawal symptoms from oral or intrathecal baclofen).

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These effects are temporary, but provide very useful information that help with the decision process.

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